New Data Highlights Salera’s Role in Accelerating Wound Healing and Reducing Scarring

Jul 29

2 min read

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A recent study and clinical case series shared by MTF Biologics provide strong evidence for the effectiveness of Salera, a dehydrated human amnion/chorion-derived allograft (dHACA). Compared to amnion-only grafts or standard care, Salera demonstrated measurable improvements in wound healing, tissue regeneration, and inflammation reduction.

Study Overview: Investigating the Mechanism of Action(Salera's role in accelerating wound healing)

Researchers at Northwestern University Feinberg School of Medicine evaluated Salera using a diabetic mouse model designed to replicate delayed wound healing. The study, published in Experimental Cell Research and available here, found that dHACA significantly improved healing outcomes over amnion-only grafts.

Key findings include:

Faster wound closure and re-epithelialization
Greater density of endothelial cells, supporting revascularization
Reduction in pro-inflammatory M1 macrophages
Suppression of pro-fibrotic gene expression

The presence of both the amnion and chorion layers in Salera contributes to its higher concentration of growth factors and structural proteins, which may help shift the wound environment toward resolution and regeneration.

Clinical Case Studies Show Real-World Impact

The new Salera MOA outlines case-based applications that support the laboratory findings. (Salera's role in accelerating wound healing)

Case 1: Implant-Based Breast Reconstruction Salvage

A 65-year-old breast cancer patient with a history of radiation therapy experienced wound breakdown and implant exposure. Following application of the Salera Mini-Membrane, the wound remained closed over a 60-day period with no complications. Remarkably, even the patient's prior hypertrophic scarring showed improvement.

Case 2: Lower Extremity VLU Wound with STSG

A 72-year-old male with a venous stasis ulcer underwent excision and negative pressure wound therapy. After revascularization, Salera was applied in conjunction with a split-thickness skin graft. The graft took successfully, and wound closure was achieved with excellent cosmetic results.

Why This Matters:

For reconstructive and wound care specialists, Salera represents a clinically backed option to promote:

Faster healing and improved revascularization
A more anti-inflammatory wound environment
Reduced scarring and fibrotic signaling
Broader application potential in complex or compromised tissue cases, including post-radiation wounds